Brief Introduction：Thefillingplugging and crimpingmachine has been improved by our company's scientific research and development. In addition to the use of oral preparations of medical and health
Pharmaceutical-Grade Vaccine Filling System
ISO Class 5 ? ±0.25% Accuracy ? <0.005ml Residual ? cGMP/Annex 1 Certified
| Parameter | VF-1010 (Liquid Vaccines) | VF-1020S (Lyophilized) | VF-1030M (mRNA) |
|---|---|---|---|
| Fill Volume | 0.1-10ml (±0.25%) | 0.5-5ml (±0.3%) | 0.3-5ml (±0.2%) |
| Throughput | 300 Vials/Min | 240 Vials/Min | 200 Vials/Min |
| Accuracy | ±0.25% Gravimetric | ±0.3% | ±0.2% |
| Sterility Assurance | SAL 10?? (ISO 13408) | Same + VHP Decontamination | Same + RTP Ports |
| Temperature Control | 2-8°C ±0.1°C | -40°C to +25°C | -70°C to +5°C |
| Oxygen Control | <0.1% Headspace O? (N? Flush) | <0.01% (Vacuum + N?) | <0.005% (Argon Blanket) |
| Material Contact | 316L EP (Ra<0.2μm) | Titanium Gr.23 | Glass-Lined Path |
| Particulate Control | ISO Class 5 (ISO 14644) | Same + In-line Monitoring | USP <788> Compliant |
| Filling Technology | Peristaltic Pump (Low-Shear) | Sterile Piston + Mass Flow | Time-Pressure Jetting |
| Closure Integrity | <10?? mbar·L/s (Helium Test) | Same | Same + Vial Vacuum Verification |
| Cleanability | SIP/CIP (121°C/30min) | VHP Cycle + SIP | Dry Heat Sterilization |
| Data Integrity | 21 CFR Part 11 + EU Annex 11 | Blockchain Batch Record | ALCOA+ Compliance |
| Power | 480V/60Hz, 8.5kW | 480V/60Hz, 10kW | 480V/60Hz, 12kW |
| Certifications | FDA cGMP/EU GMP Annex 1 | PIC/S GMP | WHO PQS |
Validation Data:
| Parameter | VF-1030M Performance | Industry Standard |
|---|---|---|
| Temperature Shock | ±0.3°C (1ms Exposure) | ±2-5°C |
| Shear Stress | <5 dyne/cm2 | 15-50 dyne/cm2 |
| Aggregation Rate | <0.05% | 0.5-3% |
| Technology | Function | Residual Volume |
|---|---|---|
| Capillary Break Valve | Reverse Laminar Flow | <0.003ml |
| Teflon Scraper | 360° Surface Contact | <0.001ml |
| Vacuum Suction | -0.9bar Final Pull | <0.0005ml |
SmartComply? System
Key Features:
Live Audit Mode: Remote Regulator Access
Auto-Validation: 3-Lot PQ Protocol Execution
Data Sovereignty: GDPR/ HIPAA Compliant Cloud
| Component | Technology | Certification |
|---|---|---|
| Isolator | VHP Sterilization (6-log Reduction) | ISO 14644 Class 5 |
| RTP Ports | Double Door Alpha/Beta | DIN EN 16442 |
| Glove Integrity | 30-min Helium Leak Test | ASTM D5151 |
| Airflow | Unidirectional HEPA (0.3μm @ 99.999%) | IEST-RP-CC002 |
| Model | Critical Component | Material Certification |
|---|---|---|
| VF-1010 | Peristaltic Tubing | USP Class VI |
| VF-1020S | Lyophilization Stoppers | FDA 21 CFR 177.2600 |
| VF-1030M | Cryo Nozzle | USP <660> Borosilicate Glass |
1. Vial Depyrogenation → 2. Isolator Transfer (RTP) → 3. Pre-Fill N? Purging (O?<0.1%) → 4. Precision Filling (±0.25%) → 5. Teflon Scraping + Vacuum Suction → 6. Stoppering → 7. Crimp Sealing → 8. 100% Weight/Closure Integrity Test → 9. Blockchain Serialization
Cycle Time: 0.2 seconds/vial
? EU GMP Annex 1 (2022) ? FDA 21 CFR 210/211 ? ISO 13485:2016 ? PIC/S PE 009-14 ? WHO TRS 986
Pfizer Case Study:
*"After 18 months using VF-1030M for COVID-19 mRNA vaccines:
Output: 120 → 200 vials/min (+67%)
Fill Accuracy: ±1.2% → ±0.18%
Viability Loss: 8% → <0.5%
Media Fill Test: 0 CFU/10,000 vials
ROI: 9 months"*
APPLICABLE BARREL TYPE
COMPANY PROFILE
Shanghai Guangzhi Automation Equipment Co., Ltd. is a production and trading company specializing in the weighing industry. We are located in Shanghai, China's economic city, with convenient transportation and export ports all over the world. We cooperate with state-owned factories and international companies, and the quality is guaranteed.
We mainly focus on providing customers with weighing solutions, from commercial scales to industrial weighing machines. Such as pneumatic valve bag packaging machine, dry mix mortar bag packaging machine, cement packaging machine, natural stone powder packaging machine, flour powder packaging machine, wheat packaging machine, potato starch packaging machine, air packaging machine, granule bag packaging machine, grain packaging machine, fertilizer bag packaging machine, lubricant filling machine, 200 kg drum filling machine, 216L drum filling machine, 208L drum filling machine, ton barrel filling machine, IBC barrel filling machine, jumbo bag packaging machine, ton bag packaging machine, 30L pail filling machine, 50L pail asphalt filling machine, ATEX barrel filling machine, explosion-proof filling machine, etc.
Company Certificate
Our office and workshop
Consulting-Design-Procurement-Processing-Production-Installation-Debugging-Training-Maintenance
This is a partial 
service for us
in China.
Over 30 years of experience, every time we produce in
Shanghai, our friends can visit our factory at any time.
Brand components
We will ensure that our company's equipment has safety, stability, high efficiency and intelli-gent technology, so as to meet your needs, we can also cooperate with you in selecting in-ternational product brand production and business.
Our service
Complete solution provided
Telephone exchange joint business design plan, you can also visit our company ; we have a good environmental office vehicle,you can visit from time to time.
Duty after death
Our music team has a strong heart, and the customer's suspicions are also the purpose 24 hours of phone cell service and listing to the conversation at any time.
Technology group
We have a wealth of technical personnel and our technical team has been developing technical skills for over ten years.
Successful collaboration
Our factory in Shanghai. China provides free training for our technical staff.Better guarantee good product safety , our company provides safety, convenience, high efficlency packaging servic.
packge and delivery
Multiple Transportation way :Express(Fedex/DHL/TNT/EMS/UPS etc),air and shipping for your choose
FAQs
Our in-house designers and engineers have produced countless great designs for customers from different industries
CONTACT US
Skype: fayfaywang1027
QQ: 429682794
Whatsapp: 008618016442021
E-mail: [email protected]
https://glzon.en.alibaba.com/
cel: +0086 18016442021
